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KMID : 0377619770320010011
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Korean Jungang Medical Journal
1977 Volume.32 No. 1 p.11 ~ p.16
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Petentiative Effect of Hydrocortisone on the Diuretic Action of Acetazolamide
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Abstract
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It is well known that acetazolamide exerts inhibiting action on the carbonic anhydrase activity, and thereby decreases reabsorption of Na+ and HC03 in the renal tubules. Diuretic responses by large doses of hydrocortisone and its augmentative effects on the diuretic action of acetazolamide had been reported.
This study was carried out to investigate the site and mechanism of potentiative diuretic effects induced by concomitant administration of acetazolamide and hydrocortisone by means of clearance technique in the mongrel dogs. Comparisons were made between the group of data obtained following simultaneous administrations of acetazolamide and hydrocortisone (combined drug group) and that of acetazolamide administration alone (single group).
The results of experiments were as follows;
1. The volume of urine flow and the rates of Na+ and Cl- excretions were significantly increased in the combined drug group compared to that of single drug group, however there were no significant differences in the rate of K+ excretion between two groups.
2. No significant differences in glomerular filtration rate and renal plasma flow between two groups were observed.
3. Negative free water clearance (TeH2O) were significantly decreased in the combined drug group compared to that of single drug group.
Results of the experiment strongly suggest that enhancing site of action of hydrocortisone on the diuretic action of acetazolamide is proximal tubules, and it can be speculated that the mechanism of potentiation is not only the enhancement of inhibition on the carbonic anhydrase activity, but also the involvement of unknown factors concerning chloride ion transport.
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